Evaluation of the COVID- 19 Pandemic in Iranian Children: A Narrative Review Study

  • Soghra Viesy Department of parasitology, Faculty of Paramedicine, Ilam University of Medical Sciences, Ilam, Iran
  • Ameneh Salimiyan naghani Master of Hematology, Imam Javad Naghan Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
  • Hanieh Beikmohammadi Department of Microbiology, Islamic Azad University, Qom Branch, Iran
  • Marzieh Shadpirouz Department of Applied Mathematics, Faculty of Mathematical Science, Shahrood University of Technology, Semnan, Iran
  • Sima Afrashteh Department of Public Health, School of Public Health, Bushehr University of Medical Sciences, Bushehr, Iran
  • Iman pouladi Department of Microbiology, Faculty of medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Keywords: COVID-19 Pandemic, Corona Virus, Iranian Children


The World Health Organization (WHO) declared the coronavirus accession as a global pandemic on 11th March 2020. COVID-19 infection outcrops in all age groups, and children might be less probably to become infected or, if infected, may show milder signs. We searched MEDLINE via PubMed, Scopus, Web of Science Core Collection (WoS), Science Direct, Google Scholar (as English databases); Magiran, Iran Medex, Iran Doc, and SID (as Persian databases). In this study, more than 80 publications from December 2019 to mid-September 2020 were reviewed with the most relevant papers about COVID-19 in children. According to the latest reports of previous studies treatmentd in Iran, the average age of children with COVID-19 infection has been reported as ranging from less than 4 months to 15 years. Also, most reported cases were males. Death in this age group was rare, but it can simply occur in children with severe conditions. The all over course of sickness, mainly pulmonary involvement- of the infected children tend to be milder compared to adults. Laboratory tests and computed tomography (CT) scan findings were nonspecific and milder compared to those at older ages. It should be noted that there is no specific passd medication for treatment of COVID-19-infected children. According to recent reports, COVID-19 characteristicss in children are not yet fully understood, which poses a remarkable problem for children's medical specialists. It should be considered that most children are asignatic or have mild signs and signs.


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Shahbaznejad L, Navaeifar MR, Abbaskhanian A, Hosseinzadeh F, Rahimzadeh G, Rezai MS. Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran. BMC Pediatrics 2020; 20:2-12

Kiani M, Mohammadpour-Mir A, Sorkhi H, Esmaeili Dooki M, Nikpour M, Babazadeh K, et al. Multiorgan Presentation of Children with COVID-19 Infection in the North of Iran: A Retrospective Study. Int J Pediatr 2021; 9(4): 13411-419.

Beheshtkhoo N, Alipour MH, Nemati R, Baghbani R, Behzad F, Shafiee M. A Review of COVID-19: The Main Ways of Transmission and some Prevention Solutions, Clinical Symptoms, more Vulnerable Human Groups, Risk Factors, Diagnosis, and Treatment. Journal of Environmental Treatment Techniques 2020; 8(3): 884-893.

Jun Yasuhara, Kae Watanabe, Hisato Takagi, Naokata Sumitomo, Toshiki Kuno, COVID‐19 and multisystem inflammatory syndrome in children: A systematic review and meta‐analysis, Pediatric Pulmonology 2021;56:252–263

World Health Organization. WHO Coronavirus (COVID-19) Dashboard. Avaliable at: https://covid19.who.int/27 Aguest 2020.

Ziaee V , Assari R, Mamishi S, Zeinaloo A, Mohammadpour M, Malekzadeh I. An Algorithmic Approach to Multisystem Inflammatory Syndrome in Children with COVID-19: Tehran Children’s Medical Center Protocol. Iran J Pediatr 2020 October; 30(5):e108617.

Mahmoudi Sh, Mehdizadeh M, Shervin Badv R, Navaeian A, Pourakbari B, Rostamyan M, et al. The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children’s Referral Hospital. Infection and Drug Resistance 2020; 13:2649–2655.

Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology 2020; 200432.

Lan L, Xu D, Xia C, Wang S, Yu M, Xu H. Early CT Findings of Coronavirus 2019 (COVID-19) in Asymptomatic Children: A Single-Center Experience. Korean J Radiol 2020; 21(7):919–924.

Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, and diagnosis, treatment and prevention options in children. The Pediatric infectious disease journal 2020; 39(5):355.

Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. The Lancet Infectious Diseases 2020. 20(6):689-696.

Gharehbaghi G, Yousefzadegan S, Javid A, Esfahani HR, Mousavi A, Mahdavynia S, et al. COVID-19 in Children and Neonates: A Comprehensive Review Article. Iran J Pediatr 2021; 31(1):e108095.

He F, Deng Y, Li W. Coronavirus disease 2019: what we know? J Med Virol 2020; 92(7):719–725.

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020; e20200702.

Mamishi S, Heydari H, Aziz-Ahari A, Shokrollahi MR, Pourakbari B, Mahmoudi Sh, et al., Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: Atypical CT manifestations and mortality risk of severe COVID-19 infection. Journal of Microbiology, Immunology and Infection 2020; 07.019.

World Health Organization. Coronavirus disease 2019 (COVID19): situation report. 2020 May 30. p. 131. 4.

Naseri A, Hosseini MS. Do Not Neglect the Children: considerations for COVID-19 Pandemic. Indian Pediatr 2020.

Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr 2020; 63(4):125–32.

Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239–42.

Bahrami A, Vafapour M, Moazzami B, Rezaei N. Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran. journal of Paediatrics and Child Health (2020):1-4.

Rahimzadeh G, Ekrami Noghabi M, Kadkhodaei Elyaderani F, Navaeifar MR, Enayati AA, Manafi Anari A, et al. COVID-19 Infection in Iranian Children: A Case Series of 9 Patients. Journal of Pediatrics Review 2020; 8(2):139–44.

Livingston E, Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy. JAMA 2020; 323(14):1335.

Pediatrics AAO. Children and COVID-19: State-level data report. Available at: Services aap org/en/pages/2019-novel-coronavirus-covid-19- infections/children-and-covid-19-state-level-data-report. 2020.

Nabian M.H, Vosoughi F, Najafi F, Khabiri SS, Nafisi M, Veisi J, et al., Epidemiological pattern of pediatric trauma in COVID-19 outbreak: Data from a tertiary trauma center in Iran, Injury 2020;13(7):1-5.

Esmaeeli H , Ghaderian M, Sayadpour Zanjani K, Ghalibafan SF, Mahdizadeh M, Aelami MH. COVID-19 in Children with Congenital Heart Diseases: A Multicenter Case Series from Iran. Case Reports in Pediatrics 2021; 2021:1-5.

Mamishi S, Heydari H, Aziz-Ahari A, Shokrollahi MR, Pourakbari B, Mahmoudi S, et al. Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: atypical CT manifestations and mortality risk of severe COVID-19 infection. Journal of Microbiology, Immunology and Infection. 2021; 54(5):839-44.

Sahraian MA, Gheini MR, Rezaeimanesh N, Ghajarzadeh M, Moghadasi AN. Knowledge regarding COVID-19 pandemic in patients with multiple sclerosis (MS): A report from Iran. Multiple sclerosis and related disorders. 2020; 42:102193.

World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations: scientific brief. Geneva: WHO; 2020, [cited 2020 Mar 27]. Available from: http: //WHO/2019-nCoV/Sci_Brief/Transmission _ modes/2020.1.

Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 2020; 7(1):11.

Navaeian A, Mahmoudi S, Pourakbari B, Bakhtiari M, Khodabandeh M, Abdolsalehi MR, et al. COVID-19 infection in children with underlying malignancies in Iran. Journal of Basic and Clinical Physiology and Pharmacology. 2021.

Shahbaznejad L, Rouhanizadeh H, Navaeifar MR, Hosseinzadeh F, Movahedi FS, Rezai MS. Clinical characteristics and outcomes of COVID-19 in children in northern Iran. International journal of pediatrics. 2021; 2021.

Perlman S. Another Decade, another Coronavirus. N Engl J Med. 2020; 382(8):760–2.

Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics 2020; 145(6).

Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. N Engl J Med 2020; 382(17):1663–5.

Mohammadi M, Arabzadeh S A M, Mollaei H R, Monavari S H, Nikpour N. Frequency of Coronavirus NL63 Infection in Children with Upper Respiratory Infection by Real-Time PCR, Iran J Pediatr. Online ahead of Print; 30(3):e101905.

Lu Q, Shi Y. Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. J Med Virol 2020; 92(6):564–7.

Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr 2020; 16(3):251– 9.

Chen ZM, Fu JF, Shu Q, Chen YH, Hua CZ, Li FB, et al.Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr 2020; 16(3):240–6.

Wang J, Shi Y. Managing neonates with respiratory failure due to SARS-CoV-2 - Authors’ reply. Lancet Child Adolesc Health 2020; 4(4):e9.

Zheng F, Liao C, Fan QH, Chen HB, Zhao XG, Xie ZG, et al. Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci 2020; 40(2):275–80.

Hong H, Wang Y, Chung HT, Chen CJ. Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Pediatr Neonatol 2020; 61(2):131–2.

Molloy EJ, Bearer CF. COVID-19 in children and altered inflammatory responses. Pediatr Res 2020; 88(3):340–1.

Yousefzadegan S, Rezaei N. Case Report: Death due to COVID-19 in Three Brothers. Am J Trop Med Hyg 2020; 102(6):1203–4.

Cai J, Xu J, Lin D, Xu L, Qu Z, Zhang Y, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis 2020 Feb 28.

Lai C-C, Liu YH, Wang C-Y, Wang Y-H, Hsueh S-C, Yen M-Y, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): facts and myths. J Microbiol Immunol Infect 2020 Jun; 53(3):404e12.

Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology 2020 Apr; 295(1):202e7.

Cruz AT, Zeichner SL. COVID-19 in children: initial characterization of the pediatric disease. Pediatrics. 2020; 145:6.

Sepandi M, Taghdir M, Alimohamadi Y, Afrashteh S, Hosamirudsari H. Factors associated with mortality in COVID-19 patients: a systematic review and meta-analysis. Iranian journal of public health. 2020; 49(7):1211.

Badawi A, Ryoo SG. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis. International Journal of Infectious Diseases. 2016; 49:129-33.

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020; 10(10):1016

Zhao X, Zhang B, Li P, Ma Ch, Gu J, Hou P, et al. incidence clinical characteristics and prognosis factor of patients with covid 19: a systematic review and meta-analysis. Medrxiv.2020; 03(17):20037572

Talebpour M, Hadadi A, Oraii A, Ashraf H. Rationale and design of a registry in a referral and educational medical center in Tehran, Iran: Sina Hospital Covid-19 Registry (SHCo-19R). Frontiers in Emergency Medicine. 2020; 4(2s):e53-e

Mirahmadizadeh A, Pourmontaseri Z, Afrashteh S, Hosseinzadeh M, Karimi J, Sharafi M. Sensitivity and specificity of chest computed tomography scan based on RT-PCR in COVID-19 diagnosis. Polish Journal of Radiology. 2021; 86:e74

Amanollahi A, Sotoodeh Ghorbani S, Basir Ghafouri H, Afrashteh S, Hashemi Nazari SS. Which criteria were used to describe patients with COVID-19? A systematic review and meta-analysis of clinical, laboratory, and imaging features. Medical Journal of the Islamic Republic of Iran (MJIRI). 2021; 35(1):848-58

How to Cite
Viesy, S., Salimiyan naghani, A., Beikmohammadi, H., Shadpirouz, M., Afrashteh, S., & pouladi, I. (2022). Evaluation of the COVID- 19 Pandemic in Iranian Children: A Narrative Review Study. Journal of Environmental Treatment Techniques, 10(3), 216-223. Retrieved from https://dormaj.org/index.php/jett/article/view/578
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