Interaction of Parasitemia, Haemato-Biochemical Indices and Gross Reproductive Pathology of Rabbit Bucks Infected with Trypanosoma Brucei Brucei

  • Imaben Grace Opaluwa-Kuzayed Department of Theriogenology and Production, University of Jos, Plateau State, Nigeria
  • Stanley David Oziegbe Department of Theriogenology and Production, University of Jos, Plateau State, Nigeria
  • Francis Elisha Sa’Ayinzat Department of Theriogenology and Production, University of Jos, Plateau State, Nigeria
Keywords: Rabbit, Trypanosoma brucei brucei, Health status haemoglobins, Blood proteins, Infertility



This study was designed to determine the interaction between parasitaemia, haemato-biochemical indices and gross reproductive pathologies of 20 adult rabbit (bucks), experimentally infected with Trypanosoma brucei over a period of 12 weeks. Ten out of the 20 rabbit bucks were inoculated intraperitoneally with 1ml of saline diluted blood containing 1 x 106 trypanosomes T. brucei brucei, while the remaining ten rabbit bucks were left uninfected. The infected rabbit bucks were monitored for nine weeks, while the others served as control post infection. Parasitaemia was present at day six in the group A animals with mean values of 2.90±0.31, after which there were fluctuations in the levels of parasitaemia. Peak parasitaemia was attained at day 10 post infection having mean value of 3.00±0.33. The overall mean parasitaemia was 1.99 ± 0.25. There was progressive decrease in PCV with mean values of 40.07 ± 0.49 % and 36.42 ± 1.15 % for the control and infected groups, respectively. Haemoglobin concentrations had mean values of 14.31 ± 1.01a g/dl and 12.21 ± 0.39b g/dl for the control and infected groups, respectively, while plasma protein concentrations of infected and control groups had mean values of 6.48 ± 0.08a gms/100ml and 6.41 ± 0.17b gms/100ml, respectively. The study revealed a significant decrease (p˂0.05) in haematological values and plasma protein concentrations of rabbit bucks infected with Trypanosoma brucei when compared to the control. It is therefore concluded that the metabolism and health status of rabbits infected with T. brucei brucei are altered which might lead to increased mortality, infertility and or sterility.


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Agu WT, Bajeh ZT. An outbreak of Trypanosoma brucei brucei in pigs, in Benue State, Nigeria. Tropical Veterinary. 1986;4:25-28.

Egbe-Nwiyi TN, Igbokwe IO, Onyeyili PA. Pathogenicity of Trypanosoma congolense infection following oral calcium chloride administration in rats. African Journal of Biomedical Research. 2005;8:197-201.

Ikede BO. Control of animal trypanosomiasis in Nigeria as a strategy for increased livestock production. Proceedings of a Preparatory Workshop, held at Vom, Plateau State, Nigeria, June 5-9. Hunter RH (1977). Physiological factors influencing ovulation, fertilization, early embryonic development and establishment of pregnancy in pigs. British Veterinary Journal. 1989;133:461-470.

Markand S, Saul A, Roon P,et al. Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase deficient mice: a model of mild hyperhomocysteinemia. Investigative Ophthalmology and Visual Science. 2015.

Obioha FC. A Guide to Poultry Production in the Tropics. Enugu: Acena Publication. 1992;1-5.

Office of International Epizootics (OIE). Manual of standards for diagnostic tests and vaccines. Third edition, 1996. Office International des Epizooties (World Organ. Anim. Health), Paris. 1997;723 (ISBN: 92-9044-423-1).

Ogunsanmi AO, Akpavie SO, Anosa, VO. Serum biochemical changes in WAD sheep experimentally infected with Trypanosoma brucei brucei. d’Elevage et de Medicine in dogs. Isreal Journal of Veterinary Medicine. 1994;49(1):36-39.

Ogwu D. Effects of Trypanosoma vivax infection on Female Reproduction in Cattle. Ph.D thesis in the Department of Surgery and Medicine, Faculty of Vet. Med., Ahmadu Bello University, Zaria, 1983.

Omotainse SO, Anosa VO, Falaye C. Clinical and biochemical changes in experimental Trypanosoma brucei brucei infection in dogs. Israel Journal of Veterinary Medicine 1994;49(1):36-

Rajappa GP. "Solving Combinatorial Optimization Problems Using Genetic Algorithms and Ant Colony Optimization." PhD Dissertation, University of Tennessee. 2012.

Ramírez-Iglesias JR, Eleizalde MC, Gómez-Piñeres E, Mendoza M. Open Vet. J., 2012; Vol. 2: 78-82.

Seifert HSH. Trop. Anim. Health Kluwer Acad. Publ., Dorrech, Bonston, London, 1996; pp. 53-260. ISBN: 0-7923- 3821-9.

Takeet MI, Fagbemi BO. Haematological, Pathological and Plasma Biochemical changes in rabbits experimentally infected with Trypanosoma congolense. Science World Journal., 2009; 4:597-6343.

Abebe G. Trypanosomosis in Ethiopia. Review Article. The Biological Society of Ethiopia. Ethiopia Journal of Biological Sciences. 2005;4(1):75-121.

Baker FJ, Silverton RE. Introduction to Medical Laboratory Technology, 6h Edition, Butterworthand Co. Publ. Limited., U.K.,1985;408.

Benjamin MM. Outline of veterinary Pathology, 3rd Ed. Kalyami Publ., New Delhi, India. 1985.

Herbert W.J, Lumsden, W.H.R. Trypanosoma brucei: A rapid “matching” method for estimating the host’s parasitaemia. Experimental Parasitology. 1976;40:427-431.

Mbaya AW, Nwosu CO, Kumshe HA. Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in their treatment. Theriogenology., 2011;16:721-728.

Onifade AA, Abu OA, Obiyan RJ, Abanikannda OTF. Rabbit Production in Nigeria: Some aspects of current status and promotional strategies. World Rabbit Science,1999;7(2):51-58.

Sadique NA, Adejinmi JO, Ariri H. Haematological and plasma protein values of Zebu cattle in trypanosome endemic zone. Tropical Animal Production Investigation. 2001;4:219-223.

Ajala MK, Balogun JK. Economics of rabbit production in Zaria, Kaduna State. Tropical Journal of Animal Science, 2004;7(1):1-10

Omole AJ, Omueti O, Ogunleke OJ. Performance characteristics of weaned rabbits fed graded levels of dry cassava peel fortified with soycorn residue basal diet 2005.

Rajora VS, Raina AK, Sharma PD, Singh B. Serum protein changes in buffalo calve experimentally infected with Trypanosoma evansi. Indian Journal of Veterinary Medicine. 1968;6:65-73.

Alayande MO, Adeyeye AA, Abdulrafiu A, Adio MB, Halilu L.L. Sexual dimorphism of rabbit bucks and does experimentally infected with Trypanosoma brucei brucei. Veterinaria. 2019; 68:82-85.

Sekoni VO. Animal Trypanosomiasis and Reproductive Disorders. Paper presented at a symposium in National Animal Production Research Institute, on the 25th April 1991.

Adeyeye AA, Alayande MO, Adio MB, Haliru L.L, Abdulrafiu A. Time-dependent testicular and epididymal damage in rabbit bucks experimentally infected with Trypanosoma brucei brucei. Macedonian Veterinary Review. 2021;44(2):139-147.

Waindi EN, Gombe S, Odour-Okelo D. Plasma testosterone in Toggerburg goats. Archives of Andrology. 1986;17:9-17.

Ikede BO, Akpavie SO. Delay in resolution of trypanosoma induced genital lesions in male rabbits infected with T. brucei and infected with Diminazene aceturate. Research in Veterinary Science. 1982;32;374-376.

Sekoni VO. Effects of T. vivax infection of sperm characteristics of yankasa rams. British Veterinary Journal. 1992;148:501-506.

Sekoni VO, Kumi-Diaka J, Saror D, Njoku C. The effects of T. vivax and T. congolense infection on the reaction time and semen characteristics in the zebu bull. British Veterinary Journal. 1988a;144:388-394.

Mutayoba BM, Eckersall PD, Cestnik V, et al. Effects of T. congolense on pituitary and adrenocortical function in sheep. Changes in the adrenal gland and cortisol secretion. Research in Veterinary Science. 1995;58:174-179.

How to Cite
Opaluwa-Kuzayed, I., Oziegbe, S., & Sa’Ayinzat, F. (2023). Interaction of Parasitemia, Haemato-Biochemical Indices and Gross Reproductive Pathology of Rabbit Bucks Infected with Trypanosoma Brucei Brucei. Journal of Infertility and Reproductive Biology, 10(3), 81-86. Retrieved from
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