The Impact of COVID 19 Pandemic on Pregnancy Outcomes of ART Cycles
The aim was to detect the rate of Covid-19 positivity in asymptomatic infertile patients admitted to ART Department during the pandemic and also investigated the effect of the Covid-19 pandemic on early pregnancy loss rates and pregnancy outcomes of ART cycles in Turkey. This cross‐sectional study presents an analysis of prospective data collected at a single tertiary hospital. 346 couples were screened for Covid -19 PCR positivity during the pandemic. 185 fresh, non-donor, IVF pregnancies were reviewed in periods of 1 year before and after the Covid-19 pandemic. A total of 346 asymptomatic infertile couples were screened for Covid-19 positivity upon admission to the hospital for infertility treatment during the pandemic and Covid-19 positivity was defined as 2.1 %. The groups were compared in terms of clinical and laboratory parameters; there were significant differences in peak E2 levels, gonadotropin duration day, gonadotrophin dose, endometrium thickness, and >14 mm follicle count on HCG trigger day. There were no significant differences in the oocyte, M2, 2PN number, the total number of the embryos between the groups. When the study and control groups were compared in terms of early pregnancy losses the results were found to be similar. Although there was a difference in the drug requirement and response required for ovarian hyperstimulation, no difference was found in the number of oocytes collected, the number of M2, and the number of embryos obtained. In our study, this situation did not affect the rates of early pregnancy loss.
World Health Organization (WHO). (2020). WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020.
ESHRE. ESHRE guidance on recommencing ART treatments. 2020.
ASRM. Patient management and clinical recommendations during the coronavirus (COVID-19) pandemic 16 May 2020 .
BFS & ARCS. U.K. best practice guidelines for reintroduction of routine fertility treatments during the COVID-19 pandemic. 2020.
CFAS. Fertility care during the COVID-19 pandemic: guiding principles to assist Canadian ART clinics to resume services and care. 2020.
European Centre for Disease Prevention and Control. Contact tracing: public health management of persons, including healthcare workers, having had contact with COVID-19 cases in the European Union 16 May 2020.
Colaco S, Chhabria K, Singh N, et al. Expression of SARS CoV-2 receptor ACE2 and the spike protein processing enzymes in developing human embryos. arXiv preprint arXiv: 2004;04935. 2020.
Segars J, Katler Q, McQueen DB, e al. Prior and novel coronaviruses, COVID-19, and human reproduction: What is known?. Fertility and Sterility. 2020. doi:https://doi. org/10.1016/j.fertnstert.2020.04.025.
Ding Y, He L, Zhang Q, Huang Z, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland. 2004;203(2), 622-630. doi: 10.1002/path.1560.
Wang Z, & Xu X. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, leydig and sertoli cells. Cells. 2020;9(4), 920. doi: 10.3390/cells9040920.
Yang M, Chen S, Huang B, Zhong JM, Su H, Chen YJ, et al. Pathological findings in the testes of COVID-19 patients: clinical implications. Eur Urol Focus. 2020;6(5):1124–1129. doi: 10.1016/j.euf.2020.05.009.
Aslan MM, Uslu Yuvacı H, Köse O, et al. SARS-CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19. The Journal of Maternal-Fetal & Neonatal Medicine. 2020:1–3.74. doi: 10.1080/14767058.2020.1793318.
Qiu L, Liu X, Xiao M, et al. SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Clin Infect Dis. 2020;71(15):813–817. doi: 10.1093/cid/ciaa375
Xie C, Lu J, Wu D, et al. False negative rate of COVID-19 is eliminated by using nasal swab test. Travel Medicine and Infectious Disease. 2020; 37:101668. doi: 10.1016/j.tmaid.2020.101668.
Sule WF, Oluwayelu DO. Real-time RT-PCR for COVID-19 diagnosis: challenges and prospects. The Pan African Medical Journal. 2020; 21;35(Suppl 2):121. doi: 10.11604/pamj.supp.2020.35.24258.
Tanacan A, Erol SA, Turgay B, et al. The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020;253:31-34. doi: 10.1016/j.ejogrb.2020.07.051.
Serge R, Vandromme J, Charlotte M. Are we equal in adversity? Does Covid-19 affect women and men differently? Maturitas. 2020;138:62–68. doi: 10.1016/j.maturitas.2020.05.009
Alviggi C, Esteves SC, Orvieto R, et al. POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group. COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management. Reproductive Biology and Endocrinology. 2020; 13;18(1):45. doi: 10.1186/s12958-020-00605-z
Demirel C, Tulek F, Celik HG, et al. Failure to Detect Viral RNA in Follicular Fluid Aspirates from a SARS-CoV-2-Positive Woman. Reproductive Sciences. 2021;22:1-3.
Calvo VE, Melguizo SC, Abascal-Saiz A, et al. On behalf of the Spanish Obstetric Emergency Group, Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2 infected women: a prospective observational study, Fertility and Sterility. 2021.
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. 2020;395:809-815. doi:10.1016/s0140-6736(20)30360-3.
Wong SF, Chow KM, Leung TN, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Americal Journal of Obstetrics and Gynecology. 2004;191:292–297. Doi: 10.1016/j.ajog.2003.11.019.
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