Bioenzyme based on nanobiotechnology for cancer treatment
Biological enzymes, also known as organic catalysts, play an effective role in the treatment of cancer, especially when combined with nanoparticles using nanobiotechnology methods, their anti-tumor effect improves. Nanoparticle-based bioenzymes play an important role in improving cancer treatment by affecting tumor tissue microenvironment such as pH, glucose concentration, hypoxia and redox reaction. Moreover, by degrading the extracellular matrix of tumor tissue, nanoparticle-based enzymes cause increased accumulation of immune cells in this area, thus enhancing the efficacy of treatments based on chemotherapy, photothermal therapy, radiotherapy, and immunotherapy.This mini-review summarizes the recent progress in the field of enhancing cancer treatment methods based on nanoparticle-conjugated enzymes, presents the structure of nanoparticle-based bioenzymes and the various applications of bioenzymes, advantages and disadvantages, challenges, and conclusions.
Keywords: Bioenzyme, NanoTechnology, Cancer Therapy
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