Recent advances and new insights on antiviral effects of exosome for HPV virus

  • Arta Pouyamanesh Department of biology, Faculty of cellular and molecular biology, Shiraz University, Shiraz, Iran
Keywords: Human papilloma virus, Exosomes, Cancer therapy, Immune system.

Abstract

Human papilloma virus related cancer has become a trend over the past few decades. Although the virus has infected millions, fortunately it hasn’t led to cancer in most of the cases. However, HPV-related cancer constitutes more than 90% of cervical and between 20- 72% of oropharyngeal cancers. Various methods have been adopted to treat HPV related cancer but the search for proper cancer treatment method with the least side effect and most efficiency has not yet ended. EVs-based therapy is a novel yet promising method for cancer therapy. Exosome as a subtype of extracellular cellular vesicles (EVs), originated from multivesicular endosomal bodies and secreted by reticulocytes from different tissues and organisms, are lipid bilayer nanovesicles containing different cargos including proteins, nucleic acids, lipid and biomarkers. Duo to their biocompatibility, efficiency in material exchange and bioavailability exosomes have gained much attention in therapeutic approaches for treatment of various diseases including cancer therapy. Since exosomes have shown more advantages in comparison with other nano-sized particles, they could be the solution to our desired cancer therapy procedure. However, further experiments and investigations need to be done for this purpose. In this review, exosome-based cancer therapy has been analyzed as a plausible method for treatment of HPV related cancers.

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References

1. Pinidis, P., et al., Human papilloma virus’ life cycle and carcinogenesis. Maedica, 2016. 11(1): p. 48.
2. Horvath, C.A., et al., Mechanisms of cell entry by human papillomaviruses: an overview. Virology journal, 2010. 7(1): p. 1-7.
3. Richards, R.M., et al., Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. Proc Natl Acad Sci U S A, 2006. 103(5): p. 1522-7.
4. Harari, A., Z. Chen, and R.D. Burk, Human papillomavirus genomics: past, present and future, in Human papillomavirus. 2014, Karger Publishers. p. 1-18.
5. Mousavi, S.M., et al., Recent progress in electrochemical detection of human papillomavirus (HPV) via graphene-based nanosensors. Journal of Sensors, 2021. 2021.
6. Elrefaey, S., et al., HPV in oropharyngeal cancer: the basics to know in clinical practice. Acta Otorhinolaryngologica Italica, 2014. 34(5): p. 299.
7. Mousavi, S.M., et al., Recent advancements in polythiophene-based materials and their biomedical, geno sensor and DNA detection. International Journal of Molecular Sciences, 2021. 22(13): p. 6850.
8. Gravitt, P.E. and R.L. Winer, Natural history of HPV infection across the lifespan: role of viral latency. Viruses, 2017. 9(10): p. 267.
9. Hashemi, S.A., et al., Coupled graphene oxide with hybrid metallic nanoparticles as potential electrochemical biosensors for precise detection of ascorbic acid within blood. Analytica chimica acta, 2020. 1107: p. 183-192.
10. Price, K.A., et al., Novel strategies to effectively de-escalate curative-intent therapy for patients with HPV-associated oropharyngeal cancer: current and future directions. American Society of Clinical Oncology Educational Book, 2020. 40: p. 257-269.
11. Mousavi, S.M., et al., A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities. Artificial cells, nanomedicine, and biotechnology, 2019. 47(1): p. 1132-1148.
12. Miles, B., H.P. Safran, and B.J. Monk, Therapeutic options for treatment of human papillomavirus-associated cancers-novel immunologic vaccines: ADXS11–001. Gynecologic oncology research and practice, 2017. 4(1): p. 1-13.
13. Bahrani, S., et al., Zinc-based metal–organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study. Drug metabolism reviews, 2019. 51(3): p. 356-377.
14. Song, Y., et al., The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next. American Journal of Reproductive Immunology, 2021. 85(2): p. e13329.
15. Dubey, A., et al., Exosomes: Emerging Implementation of Nanotechnology for Detecting and Managing Novel Corona Virus-SARS-CoV-2. Asian Journal of Pharmaceutical Sciences, 2021.
16. Mousavi, S.M., et al., Graphene nano-ribbon based high potential and efficiency for DNA, cancer therapy and drug delivery applications. Drug metabolism reviews, 2019. 51(1): p. 91-104.
17. Mousavi, S., et al., Biodegradation study of nanocomposites of phenol novolac epoxy/unsaturated polyester resin/egg shell nanoparticles using natural polymers. Journal of Materials, 2015. 2015: p. 1-6.
18. Gholami, A., et al., Current trends in chemical modifications of magnetic nanoparticles for targeted drug delivery in cancer chemotherapy. Drug metabolism reviews, 2020. 52(1): p. 205-224.
19. Muthu, S., et al., Exosomal therapy—a new frontier in regenerative medicine. Stem Cell Investigation, 2021. 8.
20. Kalluri, R. and V.S. LeBleu, The biology, function, and biomedical applications of exosomes. Science, 2020. 367(6478): p. eaau6977.
21. Popowski, K.D., et al., Exosome therapeutics for COVID-19 and respiratory viruses. View (Beijing), 2021: p. 20200186.
22. Avval, Z.M., et al., Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug metabolism reviews, 2020. 52(1): p. 157-184.
23. Li, S., et al., Exosomes Modulate the Viral Replication and Host Immune Responses in HBV Infection. BioMed Research International, 2019. 2019: p. 2103943.
24. Mousavi, S., M. Zarei, and S. Hashemi, Polydopamine for biomedical application and drug delivery system. Med Chem (Los Angeles), 2018. 8: p. 218-29.
25. Yao, Z., et al., Exosomes exploit the virus entry machinery and pathway to transmit alpha interferon-induced antiviral activity. Journal of virology, 2018. 92(24): p. e01578-18.
26. Mousavi, S.M., et al., Development of clay nanoparticles toward bio and medical applications. 2018: IntechOpen London, UK.
27. Mousavi, S.M., et al., Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy. RSC Advances, 2020. 10(22): p. 12851-12863.
28. Ouyang, Y., et al., Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. Placenta, 2016. 47: p. 86-95.
29. Mousavi, S.M., et al., Data on cytotoxic and antibacterial activity of synthesized Fe3O4 nanoparticles using Malva sylvestris. Data in brief, 2020. 28: p. 104929.
30. Shi, Y., et al., Emerging role and therapeutic application of exosome in hepatitis virus infection and associated diseases. Journal of Gastroenterology, 2021. 56(4): p. 336-349.
31. Madison, M.N. and C.M. Okeoma, Exosomes: implications in HIV-1 pathogenesis. Viruses, 2015. 7(7): p. 4093-4118.
32. Gholami, A., et al., 3D nanostructures for tissue engineering, cancer therapy, and gene delivery. Journal of Nanomaterials, 2020. 2020.
33. Khatua, A.K., et al., Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells. Journal of virology, 2009. 83(2): p. 512-521.
34. Martins, S.d.T. and L.R. Alves, Extracellular vesicles in viral infections: two sides of the same coin? Frontiers in Cellular and Infection Microbiology, 2020: p. 737.
35. Mousavi, S.M., et al., Green synthesis of supermagnetic Fe3O4–MgO nanoparticles via Nutmeg essential oil toward superior anti-bacterial and anti-fungal performance. Journal of Drug Delivery Science and Technology, 2019. 54: p. 101352.
36. Rezaie, J., et al., The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application. Cell & Bioscience, 2021. 11(1): p. 1-15.
37. Ahmadi, S., et al., Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract. Journal of Experimental Nanoscience, 2020. 15(1): p. 363-380.
38. Saad, M.H., et al., A Comprehensive Insight into the Role of Exosomes in Viral Infection: Dual Faces Bearing Different Functions. Pharmaceutics, 2021. 13(9): p. 1405.
39. Mahmoudi, M., M. Taghavi Farahabadi, and S.M. Hashemi, Exosomes: Mediators of immune regulation. Immunoregulation, 2019. 2(1): p. 3-8.
40. Mousavi, S.M., et al., Development of graphene based nanocomposites towards medical and biological applications. Artificial cells, nanomedicine, and biotechnology, 2020. 48(1): p. 1189-1205.
41. Hussain, M.W.A., et al., Exosomes for Regulation of Immune Responses and Immunotherapy. Journal of Nanotheranostics, 2022. 3(1): p. 55-85.
42. Zhang, W., et al., Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions. Frontiers in Immunology, 2018. 9.
43. Ahmadi, S., et al., Green synthesis of magnetic nanoparticles using Satureja hortensis essential oil toward superior antibacterial/fungal and anticancer performance. BioMed Research International, 2021. 2021.
44. Zhou, X., et al., The function and clinical application of extracellular vesicles in innate immune regulation. Cellular & molecular immunology, 2020. 17(4): p. 323-334.
45. Mousavi, S.M., et al., Multifunctional gold nanorod for therapeutic applications and pharmaceutical delivery considering cellular metabolic responses, oxidative stress and cellular longevity. Nanomaterials, 2021. 11(7): p. 1868.
46. Caobi, A., M. Nair, and A.D. Raymond, Extracellular vesicles in the pathogenesis of viral infections in humans. Viruses, 2020. 12(10): p. 1200.
47. Ghafouri-Fard, S., et al., The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes. Front Cell Dev Biol, 2021. 9: p. 653296.
48. Bullock, M.D., et al., Exosomal non-coding RNAs: diagnostic, prognostic and therapeutic applications in cancer. Non-coding RNA, 2015. 1(1): p. 53-68.
49. Abootalebi, S.N., et al., Antibacterial effects of green-synthesized silver nanoparticles using Ferula asafoetida against Acinetobacter baumannii isolated from the hospital environment and assessment of their cytotoxicity on the human cell lines. Journal of Nanomaterials, 2021. 2021.
50. Mousavi, S.M., et al., Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications. Polymers, 2022. 14(3): p. 617.
51. Sadri Nahand, J., et al., Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: a review. International journal of cancer, 2020. 146(2): p. 305-320.
52. Tang, Z., et al., The cancer exosomes: clinical implications, applications and challenges. International journal of cancer, 2020. 146(11): p. 2946-2959.
53. Mousavi, S.M., et al., Bioinorganic synthesis of polyrhodanine stabilized Fe3O4/Graphene oxide in microbial supernatant media for anticancer and antibacterial applications. Bioinorganic Chemistry and Applications, 2021. 2021.
54. Masoumzadeh, R., Polyethyleneimine-based materials for gene therapy, bioimaging and drug delivery systems applications. Advances in Applied NanoBio-Technologies, 2021. 2(1): p. 13-16.
55. Gurung, S., et al., The exosome journey: From biogenesis to uptake and intracellular signalling. Cell Communication and Signaling, 2021. 19(1): p. 1-19.
56. Chen, L., et al., Exosomes as drug carriers in anti-cancer therapy. Frontiers in Cell and Developmental Biology, 2022: p. 34.
57. Zhao, X., et al., Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake. Biomedicine & Pharmacotherapy, 2020. 128: p. 110237.
58. Nam, G.H., et al., Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy. Advanced Materials, 2020. 32(51): p. 2002440.
59. Xu, Z., et al., Exosome-based immunotherapy: a promising approach for cancer treatment. Molecular Cancer, 2020. 19(1): p. 1-16.
60. Mousavi, S.M., et al., Polyethylene terephthalate/acryl butadiene styrene copolymer incorporated with oak shell, potassium sorbate and egg shell nanoparticles for food packaging applications: control of bacteria growth, physical and mechanical properties. Polymers from Renewable Resources, 2017. 8(4): p. 177-196.
61. Burgio, S., et al., Extracellular vesicles-based drug delivery systems: A new challenge and the exemplum of malignant pleural mesothelioma. International Journal of Molecular Sciences, 2020. 21(15): p. 5432.
62. Batrakova, E.V. and M.S. Kim, Development and regulation of exosome‐based therapy products. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2016. 8(5): p. 744-757.
63. Kučuk, N., et al., Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers. International Journal of Molecular Sciences, 2021. 22(17): p. 9543.
64. Hashemi, S.A., et al., Integrated polyaniline with graphene oxide-iron tungsten nitride nanoflakes as ultrasensitive electrochemical sensor for precise detection of 4-nitrophenol within aquatic media. Journal of Electroanalytical Chemistry, 2020. 873: p. 114406.
65. Zhuang, X., et al., Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Molecular Therapy, 2011. 19(10): p. 1769-1779.
66. Sun, D., et al., A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Molecular therapy, 2010. 18(9): p. 1606-1614.
67. Jang, S.C., et al., Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS nano, 2013. 7(9): p. 7698-7710.
68. Tian, Y., et al., A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials, 2014. 35(7): p. 2383-2390.
69. Rani, S., et al., Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Molecular Therapy, 2015. 23(5): p. 812-823.
70. Shtam, T.A., et al., Exosomes are natural carriers of exogenous siRNA to human cells in vitro. Cell Communication and Signaling, 2013. 11(1): p. 1-10.
71. Azhdari, R., et al., Decorated graphene with aluminum fumarate metal organic framework as a superior non-toxic agent for efficient removal of Congo Red dye from wastewater. Journal of Environmental Chemical Engineering, 2019. 7(6): p. 103437.
72. Syn, N.L., et al., Exosomes in cancer nanomedicine and immunotherapy: prospects and challenges. Trends in biotechnology, 2017. 35(7): p. 665-676.
73. Pitt, J.M., et al., Dendritic cell–derived exosomes for cancer therapy. The Journal of clinical investigation, 2016. 126(4): p. 1224-1232.
74. Alipour, A. and M.Y. Kalashgarani, Nano Protein and Peptides for Drug Delivery and Anticancer Agents. Advances in Applied NanoBio-Technologies, 2022: p. 60-64.
75. Kalashgarani, M.Y. and A. Babapoor, Application of nano-antibiotics in the diagnosis and treatment of infectious diseases. Advances in Applied NanoBio-Technologies, 2022: p. 22-35.
76. Moon, B. and S. Chang, Exosome as a Delivery Vehicle for Cancer Therapy. Cells, 2022. 11(3): p. 316.
Published
2022-06-20
How to Cite
1.
Pouyamanesh A. Recent advances and new insights on antiviral effects of exosome for HPV virus. AANBT [Internet]. 20Jun.2022 [cited 24May2022];3(01):1-. Available from: https://dormaj.org/index.php/AANBT/article/view/536
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