Recent advances and new insights on antiviral effects of exosome for HPV virus
Human papilloma virus related cancer has become a trend over the past few decades. Although the virus has infected millions, fortunately it hasn’t led to cancer in most of the cases. However, HPV-related cancer constitutes more than 90% of cervical and between 20- 72% of oropharyngeal cancers. Various methods have been adopted to treat HPV related cancer but the search for proper cancer treatment method with the least side effect and most efficiency has not yet ended. EVs-based therapy is a novel yet promising method for cancer therapy. Exosome as a subtype of extracellular cellular vesicles (EVs), originated from multivesicular endosomal bodies and secreted by reticulocytes from different tissues and organisms, are lipid bilayer nanovesicles containing different cargos including proteins, nucleic acids, lipid and biomarkers. Duo to their biocompatibility, efficiency in material exchange and bioavailability exosomes have gained much attention in therapeutic approaches for treatment of various diseases including cancer therapy. Since exosomes have shown more advantages in comparison with other nano-sized particles, they could be the solution to our desired cancer therapy procedure. However, further experiments and investigations need to be done for this purpose. In this review, exosome-based cancer therapy has been analyzed as a plausible method for treatment of HPV related cancers.
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