Graphene Quantum Dots and their applications: A mini-review

  • Yasamin Ghahramani Shiraz university of Medical sciences
  • Fatemeh Fallahinezhad
  • Marzie Afsa
Keywords: GQDs, Antibacterial, Stem cell

Abstract

Graphene quantum dots (GQDs) is a new class of fluorescent carbon materials that attracted increasing interest because of their special potentials for biomedical applications, their unique and tunable photoluminescence properties, high photostability, exceptional physicochemical properties, small size, and biocompatibility. This review purpose to update the latest results of The recently developed green synthetic methods of GQDs. In This article recent advanced applications of GQDs in vitro, particularly in regenerative medicine, Antibacterial activity, and Biocompatibility of GQDs, are included.

Downloads

Download data is not yet available.

References

1. Wang S, Cole IS, Li Q. The toxicity of graphene quantum dots. RSC Advances. 2016;6(92):89867-78.
2. Mousavi SM, Hashemi SA, Jahandideh S, Baseri S, Zarei M, Azadi S. Modification of phenol novolac epoxy resin and unsaturated polyester using sasobit and silica nanoparticles. Polymers from Renewable Resources. 2017;8(3):117-32.
3. Chen F, Gao W, Qiu X, Zhang H, Liu L, Liao P, et al. Graphene quantum dots in biomedical applications: recent advances and future challenges. Frontiers in Laboratory Medicine. 2017;1(4):192-9.
4. Zhu J, Tang Y, Wang G, Mao J, Liu Z, Sun T, et al. Green, rapid, and universal preparation approach of graphene quantum dots under ultraviolet irradiation. ACS applied materials & interfaces. 2017;9(16):14470-7.
5. Zhang N, Zhang L, Ruan Y-F, Zhao W-W, Xu J-J, Chen H-Y. Quantum-dots-based photoelectrochemical bioanalysis highlighted with recent examples. Biosensors and Bioelectronics. 2017;94:207-18.
6. Li LL, Ji J, Fei R, Wang CZ, Lu Q, Zhang JR, et al. A facile microwave avenue to electrochemiluminescent two‐color graphene quantum dots. Advanced Functional Materials. 2012;22(14):2971-9.
7. Pan D, Zhang J, Li Z, Wu M. Hydrothermal route for cutting graphene sheets into blue‐luminescent graphene quantum dots. Advanced materials. 2010;22(6):734-8.
8. Sohal N, Maity B, Basu S. Recent advances in heteroatom-doped graphene quantum dots for sensing applications. RSC Advances. 2021;11(41):25586-615.
9. Minati L, Torrengo S, Maniglio D, Migliaresi C, Speranza G. Luminescent graphene quantum dots from oxidized multi-walled carbon nanotubes. Materials Chemistry and Physics. 2012;137(1):12-6.
10. Dong Y, Pang H, Ren S, Chen C, Chi Y, Yu T. Etching single-wall carbon nanotubes into green and yellow single-layer graphene quantum dots. Carbon. 2013;64:245-51.
11. Wang S, Cole IS, Zhao D, Li Q. The dual roles of functional groups in the photoluminescence of graphene quantum dots. Nanoscale. 2016;8(14):7449-58.
12. Dong Y, Chen C, Zheng X, Gao L, Cui Z, Yang H, et al. One-step and high yield simultaneous preparation of single-and multi-layer graphene quantum dots from CX-72 carbon black. Journal of Materials Chemistry. 2012;22(18):8764-6.
13. Peng J, Gao W, Gupta BK, Liu Z, Romero-Aburto R, Ge L, et al. Graphene quantum dots derived from carbon fibers. Nano letters. 2012;12(2):844-9.
14. Amani AM, Hashemi SA, Mousavi SM, Abrishamifar SM, Vojood A. Electric field induced alignment of carbon nanotubes: methodology and outcomes. Carbon nanotubes-recent progress: IntechOpen; 2017.
15. Huang X, Qi X, Boey F, Zhang H. Graphene-based composites. Chemical Society Reviews. 2012;41(2):666-86.
16. Wang C, Li D, Too CO, Wallace GG. Electrochemical properties of graphene paper electrodes used in lithium batteries. Chemistry of Materials. 2009;21(13):2604-6.
17. Becerril HA, Mao J, Liu Z, Stoltenberg RM, Bao Z, Chen Y. Evaluation of solution-processed reduced graphene oxide films as transparent conductors. ACS nano. 2008;2(3):463-70.
18. Li Y, Hu Y, Zhao Y, Shi G, Deng L, Hou Y, et al. An electrochemical avenue to green‐luminescent graphene quantum dots as potential electron‐acceptors for photovoltaics. Advanced materials. 2011;23(6):776-80.
19. Tsai M-L, Tu W-C, Tang L, Wei T-C, Wei W-R, Lau SP, et al. Efficiency enhancement of silicon heterojunction solar cells via photon management using graphene quantum dot as downconverters. Nano letters. 2016;16(1):309-13.
20. Yu T, Wang F, Xu Y, Ma L, Pi X, Yang D. Graphene coupled with silicon quantum dots for high‐performance bulk‐silicon‐based Schottky‐junction photodetectors. Advanced Materials. 2016;28(24):4912-9.
21. Zhang Q, Jie J, Diao S, Shao Z, Zhang Q, Wang L, et al. Solution-processed graphene quantum dot deep-UV photodetectors. ACS nano. 2015;9(2):1561-70.
22. Song SH, Jang MH, Chung J, Jin SH, Kim BH, Hur SH, et al. Graphene: Highly Efficient Light‐Emitting Diode of Graphene Quantum Dots Fabricated from Graphite Intercalation Compounds (Advanced Optical Materials 11/2014). Advanced Optical Materials. 2014;2(11):1009-.
23. Arvand M, Hemmati S. Analytical methodology for the electro-catalytic determination of estradiol and progesterone based on graphene quantum dots and poly (sulfosalicylic acid) co-modified electrode. Talanta. 2017;174:243-55.
24. Hashemi SA, Mousavi SM, Faghihi R, Arjmand M, Rahsepar M, Bahrani S, et al. Superior X-ray radiation shielding effectiveness of biocompatible polyaniline reinforced with hybrid graphene oxide-iron tungsten nitride flakes. Polymers. 2020;12(6):1407.
25. Mousavi SM, Low FW, Hashemi SA, Samsudin NA, Shakeri M, Yusoff Y, et al. Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy. RSC Advances. 2020;10(22):12851-63.
26. Hashemi SA, Mousavi SM, Bahrani S, Ramakrishna S. Integrated polyaniline with graphene oxide-iron tungsten nitride nanoflakes as ultrasensitive electrochemical sensor for precise detection of 4-nitrophenol within aquatic media. Journal of Electroanalytical Chemistry. 2020;873:114406.
27. Mousavi SM, Low FW, Hashemi SA, Lai CW, Ghasemi Y, Soroshnia S, et al. Development of graphene based nanocomposites towards medical and biological applications. Artificial cells, nanomedicine, and biotechnology. 2020;48(1):1189-205.
28. Mousavi SM, Hashemi SA, Salahi S, Hosseini M, Amani AM, Babapoor A. Development of clay nanoparticles toward bio and medical applications: IntechOpen; 2018.
29. Iannazzo D, Pistone A, Salamò M, Galvagno S, Romeo R, Giofré SV, et al. Graphene quantum dots for cancer targeted drug delivery. International journal of pharmaceutics. 2017;518(1-2):185-92.
30. Huang H, Wang B, Chen M, Liu M, Leng Y, Liu X, et al. Fluorescence turn-on sensing of ascorbic acid and alkaline phosphatase activity based on graphene quantum dots. Sensors and Actuators B: Chemical. 2016;235:356-61.
31. Zhao J, Zhao L, Lan C, Zhao S. Graphene quantum dots as effective probes for label-free fluorescence detection of dopamine. Sensors and Actuators B: Chemical. 2016;223:246-51.
32. Kuo W-S, Chen H-H, Chen S-Y, Chang C-Y, Chen P-C, Hou Y-I, et al. Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging. Biomaterials. 2017;120:185-94.
33. Reina G, González-Domínguez JM, Criado A, Vázquez E, Bianco A, Prato M. Promises, facts and challenges for graphene in biomedical applications. Chemical Society Reviews. 2017;46(15):4400-16.
34. Mazraedoost S, Behbudi G. Nano materials-based devices by photodynamic therapy for treating cancer applications. Advances in Applied NanoBio-Technologies. 2021;2(3):9-21.
35. Yang Y, Chen S, Liu L, Li S, Zeng Q, Zhao X, et al. Increasing cancer therapy efficiency through targeting and localized light activation. ACS applied materials & interfaces. 2017;9(28):23400-8.
36. Khodadadei F, Safarian S, Ghanbari N. Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system. Materials Science and Engineering: C. 2017;79:280-5.
37. Mousavi SM, Zarei M, Hashemi SA, Ramakrishna S, Chiang W-H, Lai CW, et al. Gold nanostars-diagnosis, bioimaging and biomedical applications. Drug metabolism reviews. 2020;52(2):299-318.
38. Gholami A, Hashemi SA, Yousefi K, Mousavi SM, Chiang W-H, Ramakrishna S, et al. 3D nanostructures for tissue engineering, cancer therapy, and gene delivery. Journal of Nanomaterials. 2020;2020.
39. Fasbender S, Zimmermann L, Cadeddu R-P, Luysberg M, Moll B, Janiak C, et al. The low toxicity of graphene quantum dots is reflected by marginal gene expression changes of primary human hematopoietic stem cells. Scientific reports. 2019;9(1):1-13.
40. Kim J, Song SH, Jin Y, Park H-J, Yoon H, Jeon S, et al. Multiphoton luminescent graphene quantum dots for in vivo tracking of human adipose-derived stem cells. Nanoscale. 2016;8(16):8512-9.
41. Ghahramani Y, Javanmardi N. Graphene Oxide Quantum Dots and their applications via stem cells: A mini-review. Advances in Applied NanoBio-Technologies. 2021;2(3):54-6.
42. Chen N, He Y, Su Y, Li X, Huang Q, Wang H, et al. The cytotoxicity of cadmium-based quantum dots. Biomaterials. 2012;33(5):1238-44.
43. Gvozdyuk AA, Petrova PS, Goryacheva IY, Sukhorukov GB, editors. Synthesis of high luminescent carbon nanoparticles. Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII; 2017: International Society for Optics and Photonics.
44. Kairdolf BA, Smith AM, Stokes TH, Wang MD, Young AN, Nie S. Semiconductor quantum dots for bioimaging and biodiagnostic applications. Annual review of analytical chemistry. 2013;6:143-62.
45. Bahrani S, Hashemi SA, Mousavi SM, Azhdari R. Zinc-based metal–organic frameworks as nontoxic and biodegradable platforms for biomedical applications: review study. Drug metabolism reviews. 2019;51(3):356-77.
46. Benítez-Martínez S, Valcárcel M. Graphene quantum dots in analytical science. TrAC Trends in Analytical Chemistry. 2015;72:93-113.
47. Zhao H, Ding R, Zhao X, Li Y, Qu L, Pei H, et al. Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering. Drug Discovery Today. 2017;22(9):1302-17.
48. Lee JS, Youn YH, Kwon IK, Ko NR. Recent advances in quantum dots for biomedical applications. Journal of Pharmaceutical Investigation. 2018;48(2):209-14.
49. Qiu J, Li D, Mou X, Li J, Guo W, Wang S, et al. Effects of graphene quantum dots on the self‐renewal and differentiation of mesenchymal stem cells. Advanced healthcare materials. 2016;5(6):702-10.
50. Yang X, Zhao Q, Chen Y, Fu Y, Lu S, Yu X, et al. Effects of graphene oxide and graphene oxide quantum dots on the osteogenic differentiation of stem cells from human exfoliated deciduous teeth. Artificial cells, nanomedicine, and biotechnology. 2019;47(1):822-32.
51. Konwar A, Gogoi N, Majumdar G, Chowdhury D. Green chitosan–carbon dots nanocomposite hydrogel film with superior properties. Carbohydrate polymers. 2015;115:238-45.
52. De Menezes FD, Dos Reis SRR, Pinto SR, Portilho FL, e Mello FdVC, Helal-Neto E, et al. Graphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity. Materials Science and Engineering: C. 2019;102:405-14.
53. Avval ZM, Malekpour L, Raeisi F, Babapoor A, Mousavi SM, Hashemi SA, et al. Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug metabolism reviews. 2020;52(1):157-84.
54. Ristic BZ, Milenkovic MM, Dakic IR, Todorovic-Markovic BM, Milosavljevic MS, Budimir MD, et al. Photodynamic antibacterial effect of graphene quantum dots. Biomaterials. 2014;35(15):4428-35.
55. Hui L, Huang J, Chen G, Zhu Y, Yang L. Antibacterial property of graphene quantum dots (both source material and bacterial shape matter). ACS applied materials & interfaces. 2016;8(1):20-5.
56. Hashemi SA, Mousavi SM, Bahrani S, Omidifar N, Arjmand M, Ramakrishna S, et al. Decorated graphene oxide flakes with integrated complex of 8-hydroxyquinoline/NiO toward accurate detection of glucose at physiological conditions. Journal of Electroanalytical Chemistry. 2021;893:115303.
57. Moradlou O, Rabiei Z, Delavari N. Antibacterial effects of carbon quantum dots@hematite nanostructures deposited on titanium against Gram-positive and Gram-negative bacteria. Journal of Photochemistry and Photobiology A: Chemistry. 2019;379:144-9.
58. Sanaee MR, Manesh HD, Janghorban K, Sanaee R, Kooshesh L, Ghahramani Y, et al. The influence of particle size and multi-walled carbon nanotube on physical properties of mineral trioxide aggregate. Materials Research Express. 2019;6(6):065413.
59. Wang J, Li Q, Zhou J, Wang Y, Yu L, Peng H, et al. Synthesis, characterization and cells and tissues imaging of carbon quantum dots. Optical Materials. 2017;72:15-9.
60. Hashemi SA, Mousavi SM, Bahrani S, Ramakrishna S, Babapoor A, Chiang W-H. Coupled graphene oxide with hybrid metallic nanoparticles as potential electrochemical biosensors for precise detection of ascorbic acid within blood. Analytica chimica acta. 2020;1107:183-92.
61. Chong Y, Ma Y, Shen H, Tu X, Zhou X, Xu J, et al. The in vitro and in vivo toxicity of graphene quantum dots. Biomaterials. 2014;35(19):5041-8.
62. Nurunnabi M, Khatun Z, Huh KM, Park SY, Lee DY, Cho KJ, et al. In vivo biodistribution and toxicology of carboxylated graphene quantum dots. ACS nano. 2013;7(8):6858-67.
63. Peng C, Hu W, Zhou Y, Fan C, Huang Q. Intracellular imaging with a graphene‐based fluorescent probe. Small. 2010;6(15):1686-92.
64. Li JL, Bao HC, Hou XL, Sun L, Wang XG, Gu M. Graphene oxide nanoparticles as a nonbleaching optical probe for two‐photon luminescence imaging and cell therapy. Angewandte Chemie International Edition. 2012;51(8):1830-4.
65. Li X, Guo H, Ren S, Fan R, Yu Y, Zhang H, et al. Fluorescent labelling in living dental pulp stem cells by graphene oxide quantum dots. Artificial cells, nanomedicine, and biotechnology. 2019;47(1):115-22.
Published
2021-12-20
How to Cite
1.
Ghahramani Y, Fallahinezhad F, Afsa M. Graphene Quantum Dots and their applications: A mini-review. AANBT [Internet]. 20Dec.2021 [cited 23Sep.2021];:53-9. Available from: https://dormaj.org/index.php/AANBT/article/view/446
Section
Articles